Lignans and neolignans are dimeric natural products with an extraordinary variety of structures and biological properties.Diphenylbutadienes are a subclass of lignans rarely found in nature with cannabisin sippy cups G being the most representative example.This lignan, found in Cannabis sativa seed, has shown anti-inflammatory and antioxidant activity among other biological properties.
Different methodologies have been Wooden Dolls reported for the synthesis of cannabis G to be employed in new biological studies.We report herein a green and concise procedure based on the use of Trametes versicolor laccase for the synthesis of a new diphenylbutadiene.The developed procedure may be employed for the synthesis of cannabisin G and other analogues.